MGF

Description

What is MGF Peptide?

Mechano-growth factor peptide (MGF peptide) is a 24-amino acid carboxy-terminal fragment of the insulin-like growth factor (IGF-1) protein. It is a product of IGF-1 mRNA splicing. The expression of MGF peptide is related to tissue damage and mechanical stimuli. For example, the release of MGF peptide has been observed to increase in response to skeletal muscle injury. This is thought to induce hypertrophy in damaged muscle tissue. Some proteins found in muscle, such as titin and myomesin, are associated with the expression of this peptide in cultured murine myoblasts and myotubes. The mechanical stimuli associated with the normal growth of tissues may also result in the expression of MGF peptide. Other forms of stimulus that may be associated with the synthesis of MGF peptide are increased acidity and heat. It has been linked to improvements in facets of muscular regeneration. These include delayed myoblast fusion and improved satellite cell proliferation. MGF peptide has also been linked to protective roles against the death of nerve and heart muscle cells. Therefore, this peptide may have a role in tissue growth and repair.