Description
What is S4 or Andarine?
S4 or Andarine is a selective androgen receptor modulator (SARM) that was being researched as a potential treatment for muscle wasting, benign prostatic hyperplasia and osteoporosis.
Animal model studies revealed excellent bioavailability, tissue-selective action, more anabolic activity than Testosterone propionate, with the ability to reduce prostate weight by up to 75%.
In a nutshell, it was the most perfect performance enhancement compound in theory.
But, the adverse effects were far too grave for it to be considered a viable treatment option for any of the above mentioned conditions.
Despite having some of the best pre-clinical data, the compound was abandoned by GTX in favor of Ostarine, which continues to be researched.3
That said, Andarine has found its way into the black market and is readily available on the internet. It is being sold as an endurance booster, muscle preserving agent and a fat loss compound.
All three are traits that it does possess.
What’s not mentioned is the potential side effects that it can cause. We’ll touch on this in a bit.
For now, here are the results that you can expect with Andarine.
Andarine is not as effective as LGD-4033 or RAD-140 in building lean muscle tissue. However, it is rarely used in that capacity.
It is more commonly found in cutting cycles, where it is often stacked with Ostarine.
Here are some of the results that you can expect from it. (Based mostly on anecdotal evidence)
Increased endurance:
Andarine allows you to increase your total workload in the gym. You can perform cardio for longer. You can hit more reps. Not to mention, you can do more sets. Your recovery is much better as well. The effects are not as pronounced as what you’d get with Cardarine. But you’ll definitely feel your workouts getting easier as the compound kicks in.
Dryness:
S4 will flush out the subcutaneous water that you are holding making your muscle tissue dry and striated. Now, this is where things start to get a little murky. While it does make you look drier, the look is nowhere close to what you’d look on DHT-based orals like Masteron. Anybody who compares the two compounds visually, has an obvious dubious agenda. The takeaway is that it will make you dry, but nowhere close to AAS levels.
Vascularity:
Just like any other compound that flushes out excessive water, S4 will enhance vascularity. Your veins will be more visible and this adds to the overall cosmetic effect that many recreational users seek.
Reduced prostate weight:
If you are running DHT-based AAS, it can have a detrimental effect on your prostate health. Even if were a long term AAS user and are now suffering from the negative side effects such as benign prostatic hyperplasia, Andarine can help reduce prostate weight without exerting other negative effects.
While it is often touted as a fat loss agent, it doesn’t really boost lipolysis. None of the animal model studies have mentioned a reduction in fat mass.
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